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as Wade Wilson / Deadpool / Juggernaut (voice) / Himself
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as Nathan Summers / Cable
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as Vanessa Carlysle
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as Russell Collins / Firefist
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as Neena Thurman / Domino
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as Jack Hammer / Weasel
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as Blind Al
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as Dopinder
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as Ellie Phimister / Negasonic Teenage Warhead
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as Black Tom Cassidy
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as Headmaster
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as Yukio / Pinkie Pie
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as Piotr Rasputin / Colossus (voice)
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as Buck
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as Head Orderly Frye
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as Sergei Valishnikov
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as Peter
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as Gaveedra-Seven / Shatterstar
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as Axel Cluney / Zeitgeist
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as Jesse Aaronson / Bedlam
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as Telford Porter / Vanisher
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as Hong Kong Boss
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as Sluggo
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as Luke, Redneck #1
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as Redneck #2
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as SWAT Captain (School)
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as Bus Driver
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as Cable's Wife
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as Hope, Cable's Daughter
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as Tree Trimmer #1
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as Tree Trimmer #2
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as Prison Guard
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as Cereal Kid
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as Neighbour #1
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as Neighbour #2
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as Neighbour #3
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as Branding Boy
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as Older Russell Collins / Firefist
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as News Reporter (Irene)
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as News Cameraman
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as News Helicopter Pilot
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as Chinook Pilot
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as Black Tom Gang Member
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as Priest
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as Park Bench Couple
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as Park Bench Couple
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as Ground Church Mutant
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as Vocalist on 'Tomorrow' (singing voice)
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as Fred Savage
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as Zoo Kid (uncredited)
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as Child Protection Worker (uncredited)
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as Waving Prisoner (uncredited)
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as Sammy (uncredited)
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as Prison Guard 96S (uncredited)
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as DMC Guard (uncredited)
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as Beast (uncredited)
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as Business Passerby (uncredited)
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as Charles Xavier (uncredited)
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as Quicksilver (uncredited)
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as Cyclops (uncredited)
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as Storm (uncredited)
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as Nightcrawler (uncredited)
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as News Anchor (uncredited)
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as Thug (uncredited)
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as Mutant Prisoner (uncredited)
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as Wolverine / Logan (archive footage)
